Use of Influenza A Virus Vaccines in Seronegative Children: Live Cold-Adapted Versus Inactivated Whole Virus
Identifieur interne : 002419 ( Main/Exploration ); précédent : 002418; suivant : 002420Use of Influenza A Virus Vaccines in Seronegative Children: Live Cold-Adapted Versus Inactivated Whole Virus
Auteurs : Sandor Feldman [États-Unis] ; Peter F. Wright [États-Unis] ; Robert G. Webster [États-Unis] ; Paula K. Roberson [États-Unis] ; Josephine Mahoney [États-Unis] ; Juliette Thompson [États-Unis] ; Margaret Doolittle [États-Unis] ; Lennie Lott [États-Unis] ; Phillip Johnson [États-Unis] ; Richard C. Christoph [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1985.
Abstract
We report the safety and antigenicity of influenza A vaccines in seronegative children one to seven years of age. A natural HINI challenge that occurred shortly after completion of the vaccination program permitted an evaluation of efficacy. Twenty-eight subjects were inoculated with live cold-adapted (ca) influenza A/Washington/897/80 (H3N2), 29 with ca influenza A/California/10/78 (H1N1), 24 with inactivated whole-virus influenza A/Bangkok/79 (H3N2), and 30 with a placebo. The ca vaccines were well tolerated, whereas the inactivated vaccine caused adverse reactions in about one-third of the children. Fifty-seven percent of the ca HINI recipients showed serological responses, contrasted with 84% and 100% of subjects receiving the ca or inactivated H3N2 vaccines, respectively. None of the 16 children with induced H1N1 antibody developed clinically apparent influenza-like illness, compared with eleven of the 51 initially seronegative children who did not receive the ca H1N1 vaccine and with four of the 12 who failed to respond. Results of the efficacy field trial suggest protection against infection and symptomatic illness in children inoculated with ca HINl, despite its failure to stimulate high levels of hemagglutinin-inhibiting antibody.
Url:
DOI: 10.1093/infdis/152.6.1212
Affiliations:
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Webster</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Sections of General Pediatrics and Biostatistics, and the Departments of Infectious Diseases and Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Nasvhille</wicri:cityArea></affiliation></author><author><name sortKey="Roberson, Paula K" sort="Roberson, Paula K" uniqKey="Roberson P" first="Paula K." last="Roberson">Paula K. Roberson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Sections of General Pediatrics and Biostatistics, and the Departments of Infectious Diseases and Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Nasvhille</wicri:cityArea></affiliation></author><author><name sortKey="Mahoney, Josephine" sort="Mahoney, Josephine" uniqKey="Mahoney J" first="Josephine" last="Mahoney">Josephine Mahoney</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Sections of General Pediatrics and Biostatistics, and the Departments of Infectious Diseases and Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Nasvhille</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, Juliette" sort="Thompson, Juliette" uniqKey="Thompson J" first="Juliette" last="Thompson">Juliette Thompson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Sections of General Pediatrics and Biostatistics, and the Departments of Infectious Diseases and Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Nasvhille</wicri:cityArea></affiliation></author><author><name sortKey="Doolittle, Margaret" sort="Doolittle, Margaret" uniqKey="Doolittle M" first="Margaret" last="Doolittle">Margaret Doolittle</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Sections of General Pediatrics and Biostatistics, and the Departments of Infectious Diseases and Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Nasvhille</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Lott, Lennie" sort="Lott, Lennie" uniqKey="Lott L" first="Lennie" last="Lott">Lennie Lott</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Sections of General Pediatrics and Biostatistics, and the Departments of Infectious Diseases and Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Nasvhille</wicri:cityArea></affiliation></author><author><name sortKey="Johnson, Phillip" sort="Johnson, Phillip" uniqKey="Johnson P" first="Phillip" last="Johnson">Phillip Johnson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Sections of General Pediatrics and Biostatistics, and the Departments of Infectious Diseases and Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Nasvhille</wicri:cityArea></affiliation></author><author><name sortKey="Christoph, Richard C" sort="Christoph, Richard C" uniqKey="Christoph R" first="Richard C." last="Christoph">Richard C. 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A natural HINI challenge that occurred shortly after completion of the vaccination program permitted an evaluation of efficacy. Twenty-eight subjects were inoculated with live cold-adapted (ca) influenza A/Washington/897/80 (H3N2), 29 with ca influenza A/California/10/78 (H1N1), 24 with inactivated whole-virus influenza A/Bangkok/79 (H3N2), and 30 with a placebo. The ca vaccines were well tolerated, whereas the inactivated vaccine caused adverse reactions in about one-third of the children. Fifty-seven percent of the ca HINI recipients showed serological responses, contrasted with 84% and 100% of subjects receiving the ca or inactivated H3N2 vaccines, respectively. None of the 16 children with induced H1N1 antibody developed clinically apparent influenza-like illness, compared with eleven of the 51 initially seronegative children who did not receive the ca H1N1 vaccine and with four of the 12 who failed to respond. Results of the efficacy field trial suggest protection against infection and symptomatic illness in children inoculated with ca HINl, despite its failure to stimulate high levels of hemagglutinin-inhibiting antibody.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Feldman, Sandor" sort="Feldman, Sandor" uniqKey="Feldman S" first="Sandor" last="Feldman">Sandor Feldman</name></region><name sortKey="Christoph, Richard C" sort="Christoph, Richard C" uniqKey="Christoph R" first="Richard C." last="Christoph">Richard C. Christoph</name><name sortKey="Doolittle, Margaret" sort="Doolittle, Margaret" uniqKey="Doolittle M" first="Margaret" last="Doolittle">Margaret Doolittle</name><name sortKey="Johnson, Phillip" sort="Johnson, Phillip" uniqKey="Johnson P" first="Phillip" last="Johnson">Phillip Johnson</name><name sortKey="Lott, Lennie" sort="Lott, Lennie" uniqKey="Lott L" first="Lennie" last="Lott">Lennie Lott</name><name sortKey="Mahoney, Josephine" sort="Mahoney, Josephine" uniqKey="Mahoney J" first="Josephine" last="Mahoney">Josephine Mahoney</name><name sortKey="Roberson, Paula K" sort="Roberson, Paula K" uniqKey="Roberson P" first="Paula K." last="Roberson">Paula K. Roberson</name><name sortKey="Thompson, Juliette" sort="Thompson, Juliette" uniqKey="Thompson J" first="Juliette" last="Thompson">Juliette Thompson</name><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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